How Nutrients Orchestrate Lysosome Positioning
نویسندگان
چکیده
منابع مشابه
Mechanisms and functions of lysosome positioning.
Lysosomes have been classically considered terminal degradative organelles, but in recent years they have been found to participate in many other cellular processes, including killing of intracellular pathogens, antigen presentation, plasma membrane repair, cell adhesion and migration, tumor invasion and metastasis, apoptotic cell death, metabolic signaling and gene regulation. In addition, lys...
متن کاملHow to make a lysosome
How to make a lysosome oated vesicles had been described as early as 1961. These small membranous structures were characterized by a highly organized layer of material on the cytoplasmic surface, “but no one knew their function,” says Marilyn Farquhar, whose lab at the time had become interested in how the Golgi complex helped produce enzymes. Roth and Porter (1964) had provided evidence that c...
متن کاملPLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.
Mutations of the Plekhm1 gene in humans and rats cause osteopetrosis, an inherited bone disease characterized by diminished bone resorption by osteoclasts. PLEKHM1 binds to RAB7 and is critical for lysosome trafficking. However, the molecular mechanisms by which PLEKHM1 regulates lysosomal pathways remain unknown. Here, we generated germline and conditional Plekhm1-deficient mice. These mice di...
متن کاملA Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair
Lysosome exocytosis plays a major role in resealing plasma membrane (PM) disruptions. This process involves two sequential steps. First, lysosomes are recruited to the periphery of the cell and then fuse with the damaged PM. However, the trafficking molecular machinery involved in lysosome exocytosis and PM repair (PMR) is poorly understood. We performed a systematic screen of the human Rab fam...
متن کاملFailure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn.
Rapsyn, a scaffold protein, is required for the clustering of acetylcholine receptors (AChRs) at contacts between motor neurons and differentiating muscle cells. Rapsyn is also expressed in cells that do not express AChRs. However, its function in these cells remains unknown. Here, we show that rapsyn plays an AChR-independent role in organizing the distribution and mobility of lysosomes. In ce...
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ژورنال
عنوان ژورنال: Contact
سال: 2018
ISSN: 2515-2564,2515-2564
DOI: 10.1177/2515256418756111